Basic Information
VIS ID
TVIS10009726
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chrX
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
133450727/134316697 (Hg38)
End
133450727/134316697 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/146419; hsa-mir-105-1/Downstream/223488;
Nearest TSS
ENST00000429181/Upstream/79650; ENST00000370800/Downstream/56556;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/79249, chrX-CpG: 52/Downstream/56407
Nearby gene
CCDC160(-70919) ; PHF6(+56615) ;
Nearest cancer related gene
PHF6(TSG, +56615) ;
Upstream sequence
ccacaggcctcaaagccctccaaacgtccacttgcagattctcgaaaaagagtgtttcatagctgctctttcaaaaggaaagttcaactctgggagttga
Downstream sequence
tcaaaaaaaaaaaaaaaaaaaaaaaaaaaaattaaaaaaaagaaccccaagctaaaaaaaagaaagaaagaaattccagactagactaaatagtgaaggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate