Basic Information
VIS ID
TVIS10009732
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
29
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCA| |AGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTC
Host Sequence
Chromosome
chrX
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
140426930/141332786 (Hg38)
End
140426930/141332786 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXD
Nearest miRNA
hsa-let-7f-2/Upstream/406555; hsa-mir-105-1/Downstream/4659964;
Nearest TSS
ENST00000429181/Upstream/90290; ENST00000370518/Downstream/170063;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/155566, chrX-CpG: 130/Downstream/2300808
Nearby gene
SPANXC(-90284) ; SPANXA2-OT1(+163913) ;
Upstream sequence
ggttagggtgagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggtt
Downstream sequence
gccgggcgcggtggcgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacctgggaggcggagcttgcagtgagccgagat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate