Basic Information
VIS ID
TVIS10009741
Fusion event
HBV-PTCHD1-AS integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chrX
Cytoband
p22.11
Reference genome
GRCh37/hg19
Start
22346863/22328746 (Hg38)
End
22346863/22328746 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
PTCHD1-AS
Nearest miRNA
hsa-mir-23c/Upstream/2311559; hsa-let-7f-2/Downstream/6166809;
Nearest TSS
ENST00000429181/Upstream/55803; ENST00000456621/Downstream/99386;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/387163, chrX-CpG: 25/Downstream/1003421
Upstream sequence
CCTAAAGGGCTGGCTTTGTCACTCAACACTCTGCATTCATCTGTGTAGTCTGTCTGACTAAGCCATATGTCCTGAGAATGGTGGAGGAAGAGACTGTGCT
Downstream sequence
tttgttaattttttttttttttttttttttttttttttttttttttgagatggagtcttgctctgtcgcccaggctggagtgcagtggtgcgatctcggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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