Basic Information
VIS ID
TVIS10009748
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1936
Orient
-
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA| |CTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCC
Host Sequence
Chromosome
chrY
Cytoband
q11.221
Reference genome
GRCh37/hg19
Start
18039359/15927479 (Hg38)
End
18039359/15927479 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/2448213;
Nearest TSS
ENST00000430575/Upstream/1123446; ENST00000421205/Downstream/1573479;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/470742, chrY-CpG: 21/Downstream/1590858
Nearby gene
NLGN4Y(-1083511) ; FAM41AY1(+1573479) ;
Upstream sequence
gttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggtga
Downstream sequence
TTTGTAAttttttttttttttttttttttttttttttGCTTAAAGGCATGTACTTATTTCAACTCATGTTGAAAGCACAATCATGTGTTGAAAATGTGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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