Basic Information
VIS ID
TVIS10009763
Fusion event
HBV-SKINT1L integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr1
Cytoband
p33
Reference genome
GRCh37/hg19
Start
48572179/48106507 (Hg38)
End
48572179/48106507 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
SKINT1L
Nearest miRNA
hsa-mir-12136/Upstream/3560955; hsa-mir-101-1/Downstream/2953330;
Nearest TSS
ENST00000473358/Upstream/24311; ENST00000431986/Downstream/66465;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/108578, chr1-CpG: 67/Downstream/365125
Upstream sequence
TACTTCATTCCCTTCTCTGTTTGTTCTCCTCTATTCTGTGCAAGAAGGTTAACACTGATGGGGGAAAAGAAAAAGGAAAAATAATCTACAGCATGGGTAG
Downstream sequence
CTACACTTTAGATACATCACTTAGAGCAACTTGCTCCTATTAGACAAGTCCAAAGGGCAAGCATTACATTGAGGCATTTCTCAGATCTCTCCTTGCTGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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