Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009764
Fusion event
HBV-CADM1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
End
115149583/115278863 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-26b-5p ; hsa-mir-877-3p ; hsa-mir-484 ; hsa-mir-182-5p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-214-3p ; hsa-mir-486-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4479 ; hsa-mir-6770-5p ; hsa-mir-361-3p ; hsa-mir-4428 ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-6892-5p ; hsa-mir-4327 ; hsa-mir-6512-5p ; hsa-mir-4475 ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-3692-3p ; hsa-mir-4703-3p ; hsa-mir-140-3p ; hsa-mir-7852-3p ; hsa-mir-144-3p ; hsa-mir-101-3p ; hsa-mir-6732-3p ; hsa-mir-652-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-7161-3p ; hsa-mir-126-3p ; hsa-mir-21-5p ; hsa-mir-302c-5p ; hsa-mir-552-5p
Nearest miRNA
hsa-mir-10392/Upstream/1828775; hsa-let-7a-2/Downstream/3365137;
Nearest CpG islands
Nearest cancer related gene
CADM1(TSG, No orient, 0)
Upstream sequence
aatgctggcctgaaccagggagggaggagcagcagtctccacaggaaagatcagatcctagaattacaaggaaggagtttatacaatgtggttgatcaca
Downstream sequence
aaatggtggtgagagaggatggagggaataaaggaaaatgccaagattgagtctggaggactaggacttactgccgaagatgggaagcctggaggacgtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.