Basic Information
VIS ID
TVIS10009768
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
418
Orient
+
Integrated sequence
TCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGC| |TGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATG
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
104176280/103523930 (Hg38)
End
104176280/103523930 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/1477926; hsa-mir-1267/Downstream/4007241;
Nearest TSS
ENST00000623511/Upstream/98730; ENST00000640578/Downstream/1941937;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/677517, chr13-CpG: 29/Downstream/2969130
Nearby gene
MIR548AS(-241432) ; DAOA-AS1(+1935126) ;
Upstream sequence
TTTTTGAACATAGAAAAATCACAAAAATAAAACAATTTTGTACTTTAACAGGGAAATTATTAAAACTTGTTTAAAATTTGTTTGTTTTAGAATTCAGCTT
Downstream sequence
AAGTATACAATATCAGTTTAAATGGTGAGGGTTAAATGATGAAATTACGCAACCCGTGTATTAGGAAAGGCAGGTTACAGCTTCACAGGTCCTTTAGTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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