Basic Information
VIS ID
TVIS10009769
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1712
Orient
-
Integrated sequence
GAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCA| |AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC
Host Sequence
Chromosome
chr14
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
34842463/34373257 (Hg38)
End
34842463/34373257 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/3358515; hsa-mir-1185-1/Downstream/2579052;
Nearest TSS
ENST00000550708/Upstream/145443; ENST00000554608/Downstream/89099;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/312504, chr14-CpG: 34/Downstream/89156
Nearby gene
EGLN3(-422179) ; SPTSSA(+59681) ;
Nearest cancer related gene
EGLN3(TSG, -422179) ;
Upstream sequence
CACCAGAGTTCTAATACTCAAACTTAACCATCCCAACCCGAGCTAACTGCATTTCTTAGACTGTATGGGGAAAAAAGGAGATGTTACCAACAGGATGTTG
Downstream sequence
AACTGATTTCAACTCCTTGAGTGTGATCTCTCTTCCCTCCTGTCAGCAGGCTGGGACAGCACCCTTCTTCTTCCCTGAGGACAGATCCTGTGCCACTTCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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