Basic Information
VIS ID
TVIS10009772
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1726
Orient
-
Integrated sequence
CGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTT| |AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT
Host Sequence
Chromosome
chr15
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
80250469/79958127 (Hg38)
End
80250469/79958127 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/748256; hsa-mir-11181/Downstream/622976;
Nearest TSS
ENST00000557528/Upstream/34373; ENST00000561012/Downstream/13042;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/33969, chr15-CpG: 73/Downstream/101433
Nearby gene
ST20-AS1(-33273) ; BCL2A1(+2763) ;
Nearest cancer related gene
BCL2A1(OG, +2763) ;
Upstream sequence
tgtctgttcaaatcttttacccatgcttagtattaggttgatgatgatcttgttattgaattataagagtatcacctatcacaagtcctttatcagatat
Downstream sequence
tagtgtggtacagattgtctcccattctgtggtttgccttttTGAGAGCTtttttaaatagctttattgaggtataattcaaataccTTCTGTTTGAGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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