Basic Information
VIS ID
TVIS10009775
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1800
Orient
-
Integrated sequence
AGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT| |CTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGG
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
46475244/46441332 (Hg38)
End
46475244/46441332 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/12277659; hsa-mir-11401/Downstream/3851284;
Nearest TSS
ENST00000527434/Upstream/10654445; ENST00000569239/Downstream/142921;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/12358, chr16-CpG: 42/Downstream/179758
Nearby gene
ANKRD26P1(+28005) ;
Upstream sequence
ACCCAGGGAAAATCTTTACCTTATGCTTGAGGTAGGGACCAGGCTAAAGTGAAAGCCAGACATAAAATTCTATCTAAAATAAATCCACAATCGAAGAAAA
Downstream sequence
TATGTGGTGTACAGGCATTGAATATCTTTACTGGATCATTGACATAGTAAGATAAATTCAACTTTTTACATtgttttcttttcctccagttagggcttga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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