Basic Information
VIS ID
TVIS10009776
Fusion event
HBV-ADPRM integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1431
Orient
+
Integrated sequence
ACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACG| |TCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCAC
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10602507/10699190 (Hg38)
End
10602507/10699190 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADPRM
Nearest miRNA
hsa-mir-1253/Upstream/2512186; hsa-mir-10226/Downstream/1382709;
Nearest TSS
ENST00000595228/Upstream/815; ENST00000609540/Downstream/5710;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1308, chr17-CpG: 76/Downstream/30282
Upstream sequence
ataaaatGCTATCATTGAAAACAGTTCTTGGGgccagatgtggtggctcacgcctgtaatcccatcactttgggaggctgaggtgagtgggtcactggag
Downstream sequence
cctaggagtttgaagctgcagtgagctgtgatcgggccactgccttccagtctgggcaacaaagcaagactctgcctctaaaaaataaataaaataaaTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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