Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009778
Fusion event
HBV-ABCA5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1817
Orient
+
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr17
Cytoband
q24.3
Reference genome
Start
End
67260752/69264611 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10226/Upstream/164955; hsa-mir-1250/Downstream/5484002;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/663174, chr17-CpG: 116/Downstream/61957
Upstream sequence
ACTTTAGTTTCAAGAAATTATTTTAAAATGGTGGTAAGTTATTGTTTTTAAAAGTCACTTATCATATAAAATGATTACATGTATTAAATACCAGACACAC
Downstream sequence
TTGCTCTATTTTCTTTAACAAATTAATAACCAAATTATGCAATAAGTCAACTGTCATGTTTATAACAGATTTTAAATAACATTCTATCTATAAATAGCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.