Basic Information
VIS ID
TVIS10009779
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2750
Orient
+
Integrated sequence
TTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATT| |TACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCA
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
15180585/15180586 (Hg38)
End
15180585/15180586 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3156-2/Upstream/350344; hsa-mir-1-2/Downstream/6502932;
Nearest TSS
ENST00000575820/Upstream/16119; ENST00000579454/Downstream/5774284;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/15243, chr18-CpG: 78/Downstream/17065
Nearby gene
ANKRD30B(-327848) ; LOC644669(+132970) ;
Upstream sequence
ctaacacaggaacttgcctcttaacacatgtggtattggcttttctatctttcctgttttatttTATTCTCTCTTCCTTGTCTCACTTTTGCTGTGTCCT
Downstream sequence
CACTCCTGCTTTAAGAATACCCAAACAAATACATTCATTTATTTTTTTAGACTCTCAGAACACAGTTGATAGTTGAACTTGTAATCTATGATAATCAGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate