Basic Information
VIS ID
TVIS10009789
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2874
Orient
-
Integrated sequence
TATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCA| |ATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCC
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
51264905/52648366 (Hg38)
End
51264905/52648366 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01524 ; LOC105372666
Nearest miRNA
hsa-mir-103a-2/Upstream/1195389; hsa-mir-1-1/Downstream/1420042;
Nearest TSS
ENST00000382410/Upstream/27528; ENST00000413070/Downstream/23551;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/456080, chr20-CpG: 27/Downstream/324802
Nearby gene
ZFP64(-456381) ; TSHZ2(+324041) ;
Upstream sequence
GTGTTATAGAAGGCAGATGGAAATTTCTTTTCTTGTTGTTTAATCTTCCTTCTCATAAAAATAAGGAGAAAAGTAGTATTTCAGAGCTGATCGCATCTCT
Downstream sequence
AAATCAACAGCCAAATATCTCCCAGGGCAGAGAAAATGGAAGTAGAAATCAAGTTATTGAAAAATCAACTTAAGTTtgtgtgtgtgtgtgtgtgtgtgtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate