Basic Information
VIS ID
TVIS10009790
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2287
Orient
+
Integrated sequence
AAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTC| |CTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTC
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
19533065/19545542 (Hg38)
End
19533065/19545542 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3198-1/Upstream/1564581; hsa-let-7a-3/Downstream/418211;
Nearest TSS
ENST00000624155/Upstream/17997; ENST00000452326/Downstream/21297;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/20811, chr22-CpG: 30/Downstream/20949
Nearby gene
CLDN5(-20205) ; LINC00895(+20588) ;
Upstream sequence
gccacgACTAGTGAAACATGAGGCCTGTATTTTTGCTGGGGCAGTGAGCATCCTTGGCCACATGCTGGGCTCCAGGGGGACGGCCAGGGGCATTGGCCAG
Downstream sequence
GGAAGGAGCCCAGGAGAGCAAACAGAACCTGCATACTCACTCCCCTCCCTCCCAGTCCCATTTAATCTAACTGTGAAGACAGTGAAAACTAATAAGCCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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