Basic Information
VIS ID
TVIS10009792
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2438
Orient
+
Integrated sequence
CTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCG| |GGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACC
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
141188628/141469786 (Hg38)
End
141188628/141469786 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/7031880; hsa-mir-1224/Downstream/10096090;
Nearest TSS
ENST00000440867/Upstream/22892; ENST00000515549/Downstream/17261;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/66950, chr3-CpG: 16/Downstream/16911
Nearby gene
ZBTB38(-19996) ; RASA2(+17298) ;
Upstream sequence
caccagaacagaaacatgctatactattatccctttaaaaacctatttttcccatgtgcccttctagccactaaaatttcttccatttttttaagcaaat
Downstream sequence
cagatatctcttcaatatgctgatttcctttcttttgcatgcatacctagcagtgggattgctagatcatatcatagatctatttttagatctcagtgtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate