BCHE _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009794
Fusion event
HBV-BCHE integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1790
Orient
-
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr3
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
165529947/165812159 (Hg38)
End
165529947/165812159 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCHE
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7g/Upstream/1640603; hsa-mir-1224/Downstream/2739695;
Nearest TSS
ENST00000440867/Upstream/263321; ENST00000498413/Downstream/25261;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1807652, chr3-CpG: 23/Downstream/1567980
Upstream sequence
TCTGTGAGATAACAGTAGAATAGCACAGTTTTCAGATATCAGCATTCTGTTAATGCACATTAAAGACAAACAAACACAAAAGAATCATGGAAGATAGAAG
Downstream sequence
AGATATACAATTTTATCAGTAGCTGAACAGTTTGGAAGTACTAAAAATACTATTAATATCCTTATCCAACTATTTCTTAGACATCAATCTATCAATGGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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