Basic Information
VIS ID
TVIS10009805
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2750
Orient
+
Integrated sequence
TTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATT| |TACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCA
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
57922162/57862456 (Hg38)
End
57922162/57862456 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7A
Nearest miRNA
hsa-mir-1183/Upstream/457366; hsa-mir-10399/Downstream/5758634;
Nearest TSS
ENST00000635602/Upstream/412279; ENST00000418297/Downstream/5191975;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/26631, chr7-CpG: 153/Downstream/5620
Nearby gene
ZNF716(-388897) ;
Upstream sequence
tgggaggctgaggcagaaggatcacttgaggccaggagtttcagaccagcctgggcaacataatgagaccctgtccctacaaaaaattaaaagaaaaata
Downstream sequence
CACTCCTGCTTTAAGAATACCCAAACAAATACATTCATTTATTTTTTTAGACTCTCAGAACACAGTTGATAGTTGAACTTGTAATCTATGATAATCAGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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