Basic Information
VIS ID
TVIS10009806
Fusion event
HBV-LOC101929322 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2750
Orient
+
Integrated sequence
TTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATT| |TACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCA
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
64960709/65495796 (Hg38)
End
64960709/65495796 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
LOC101929322
Nearest miRNA
hsa-mir-1183/Upstream/816620; hsa-mir-10399/Downstream/1618526;
Nearest TSS
ENST00000635602/Upstream/32725; ENST00000434382/Downstream/377471;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/121496, chr7-CpG: 168/Downstream/12711
Nearby gene
ZNF92(-94711) ; LOC441242(+151215) ;
Upstream sequence
TTCCTCAACCTGTTGTGCTGTAAGCCTATTTTATTGATAAGAAAGAGCCAGACAAAATTGGCTGAAAATTAAAAATCTAGGTGACATATTTTAGAGGACT
Downstream sequence
CACTCCTGCTTTAAGAATACCCAAACAAATACATTCATTTATTTTTTTAGACTCTCAGAACACAGTTGATAGTTGAACTTGTAATCTATGATAATCAGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate