Basic Information
VIS ID
TVIS10009809
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1808
Orient
-
Integrated sequence
TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC| |CAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87329519/86317290 (Hg38)
End
87329519/86317290 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/6075817; hsa-mir-10400/Downstream/4888195;
Nearest TSS
ENST00000518652/Upstream/86909; ENST00000523863/Downstream/3856;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/247473, chr8-CpG: 100/Downstream/25025
Nearby gene
SLC7A13(-86915) ; WWP1(+25475) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
CCTTCACTAGCAGTTGCCTGTTCTACTCATTAAATCTAAATTAGCCAAATCTGAAACTGACTGTTGAGTACTACAGAATACTGTTTCATTAGCAATTCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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