Basic Information
VIS ID
TVIS10009813
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
577
Orient
-
Integrated sequence
CCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCA| |AACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAG
Host Sequence
Chromosome
chrX
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
25303850/25285733 (Hg38)
End
25303850/25285733 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/5268546; hsa-let-7f-2/Downstream/3209822;
Nearest TSS
ENST00000429181/Upstream/269313; ENST00000423914/Downstream/592606;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/262488, chrX-CpG: 30/Downstream/1271908
Nearby gene
ARX(-269785) ; MAGEB18(+852610) ;
Upstream sequence
gatcaacgagacagaaagtcaacaaggatacccaggaattgaactcagctctgcaccaagcatacctaatagacatctacagaactctccaccccaagtc
Downstream sequence
catttatgaggaagctggggccctcatgacctaaggacctcccttttggccccacctcccaacactgttgcatcggggattaagtttccaacacatgaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate