Basic Information
VIS ID
TVIS10009814
Fusion event
HBV-PPP1R12BP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1656
Orient
+
Integrated sequence
GTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACA| |TAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATT
Host Sequence
Chromosome
chrY
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
28425190/26279043 (Hg38)
End
28425190/26279043 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPP1R12BP1
Nearest miRNA
hsa-mir-12120/Upstream/12799777;
Nearest TSS
ENST00000430575/Upstream/550553;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/814102, chrY-CpG: 32/Downstream/130345
Nearby gene
TTTY3B(-545655) ;
Upstream sequence
agggtagaactgaataattgtgagagagaacataggtccctcaaagcctaaaatagtcactatttagtctcttacagaaagtatcctaaccccAGACTAT
Downstream sequence
AGCACAGACAAATCTACTTACATCCTTTGACCAGAAATTGATGTCTGTGCCTCTTCATCGTTCCTTGGGCCACCTCCTCTCTTGGACAGACAGCCTCTTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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