Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009815
Fusion event
HBV-AADACL4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
Start
End
12716236/12656217 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12136/Upstream/77194; hsa-mir-101-1/Downstream/4202732;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37581, chr1-CpG: 128/Downstream/856793
Upstream sequence
cggaaagttacccatggCCTTGGCTTGTCCTTGGCATGACTTGAGACAGAAGGGGAAAATAACAGTATGGTTCCCTCATGGATGGACTGGTCCTGGCATT
Downstream sequence
TTATGAAATGTCCCTTGTGATTGGCCAGCTCCATGTCCACACCAGGGAGACAGGCATCCCAGTTCCCTTGGCTGGCTGCCTCAGCATCCAGGCATCCCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.