VISDB Viral Integration Site DataBase

VIS ID

TVIS10009817

Fusion event

HBV-KMO integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

521

Orient

+

Integrated sequence

TATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCG| |GACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCC

Chromosome

chr1

Cytoband

q43

Reference genome

Start

End

241741597/241578295 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-302c-5p ; hsa-mir-106a-3p ; hsa-mir-3143 ; hsa-mir-6793-3p ; hsa-mir-302f ; hsa-mir-4803 ; hsa-mir-502-3p ; hsa-mir-501-3p

Nearest miRNA

hsa-mir-101-1/Upstream/445949; hsa-mir-3124/Downstream/1767881;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/58483, chr1-CpG: 20/Downstream/61586

Upstream sequence

tggatgaggaggaaaacaagtcctcttctccaagactcttcatgagcaccagcgctgcttgactattgggttagaactgcagacttttcttgctgagccc

Downstream sequence

agcactgcaaacatgactctgatgaaataaacttcccaccagcagaaagatgtgggactcaagtcctgctctccagattcttttgtcccatggcatgttt