Basic Information
VIS ID
TVIS10009818
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr1
Cytoband
p34.1
Reference genome
GRCh37/hg19
Start
45976721/45511049 (Hg38)
End
45976721/45511049 (Hg38)
Orient
+
Location type
UTR3
Target gene
MMACHC ; PRDX1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-7-5p ; hsa-mir-98-5p ; hsa-mir-1225-3p ; hsa-mir-342-5p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-100-5p ; hsa-let-7b-5p ; hsa-mir-510-5p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3174 ; hsa-mir-3612 ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6832-5p ; hsa-mir-6840-3p ; hsa-mir-6869-5p
Nearest miRNA
hsa-mir-12136/Upstream/965497; hsa-mir-101-1/Downstream/5548788;
Nearest TSS
ENST00000473358/Upstream/1616; ENST00000496999/Downstream/10805;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10672, chr1-CpG: 64/Downstream/10442
Upstream sequence
GCAGCTCTCCTCATTTTCCCCAAAACAGGGAAAGCAAGGAGTAAATTCCTCTTAAAATCAAAAGCTAATAATATGCTTCCTAAAATAAAGACTCATCAAG
Downstream sequence
GTCTCAGTTCAAGTTTAATACAAACTACAAAAGATTAATGGGTTGCTCTACTAATACATCATACAAACCAGTAGCCTGCCCACAACGCCAACTCAGGCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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