Basic Information
VIS ID
TVIS10009821
Fusion event
HBV-LOC105369405 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1330
Orient
-
Integrated sequence
AGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGG| |GACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTAC
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
79307272/79596228 (Hg38)
End
79307272/79596228 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369405
Nearest miRNA
hsa-mir-10392/Upstream/174002; hsa-let-7a-2/Downstream/2294513;
Nearest TSS
ENST00000527297/Upstream/155280; ENST00000526154/Downstream/16072;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/155068, chr11-CpG: 25/Downstream/3093315
Nearby gene
TENM4(-155577) ;
Upstream sequence
TAAggctgggcacggtggctcacacctgtaatcccagcactttgggaggctgaggcgggtagtttgcttgagctgaggagtttgagaccagcctgggcaa
Downstream sequence
catggtgaaaccctgtctctaccgaaaatacaaaaaaatagctgggcatggtggcacatgcctgtagtcccagctactccagaggctgaggtgggaggat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate