Basic Information
VIS ID
TVIS10009830
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2799
Orient
-
Integrated sequence
CTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACA| |TAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCA
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
184735556/183870829 (Hg38)
End
184735556/183870829 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/2565177; hsa-mir-1244-1/Downstream/508146;
Nearest TSS
ENST00000437798/Upstream/656510; ENST00000441026/Downstream/33700;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/609974, chr2-CpG: 72/Downstream/727290
Nearby gene
NUP35(-709148) ; ZNF804A(+727537) ;
Upstream sequence
CCATCTCATATACTGTGTGTTCATTACATGCCAGACATACTATTATGGTCCTGTATTCAAAGTTGGACTGTCtgctatggtatgaatttttgtgttcacc
Downstream sequence
cctaaatgtatatgttgaaatctcattcctagtgggataaggaggtgcggtctttgggaggtgattaggttatgaaagcagagcgctcatgaattacatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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