Basic Information
VIS ID
TVIS10009833
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
188803523/189085734 (Hg38)
End
188803523/189085734 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107986167 ; TPRG1
miRNAs that regulate target gene
hsa-mir-145-5p
Nearest miRNA
hsa-let-7g/Upstream/396868; hsa-mir-3137/Downstream/744188;
Nearest TSS
ENST00000440867/Upstream/108980; ENST00000479720/Downstream/14387;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/137971, chr3-CpG: 99/Downstream/1034557
Nearby gene
LPP(-195063) ; TPRG1(+86240) ;
Upstream sequence
TATTGGTGGGTACAGATCATATTCTCCAGTTTTCATAGCCATAATTGTGGCAATGAAACATTTCAGAGAAACATAACAAACACAAAAAAAGTACAGATGT
Downstream sequence
AAGTGATCTGATCCATAATGAAAAGTTCAAAGGCACAAATATTGTTACCGTTATGAAATTAATTGAAGATTAAAATCCATTTACACTTGAGGATATGGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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