Basic Information
VIS ID
TVIS10009837
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1775
Orient
-
Integrated sequence
TCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTAC| |TAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCC
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
92684362/91763211 (Hg38)
End
92684362/91763211 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/4462628; hsa-mir-1243/Downstream/7234176;
Nearest TSS
ENST00000502981/Upstream/437905; ENST00000505511/Downstream/124675;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/924095, chr4-CpG: 26/Downstream/419255
Nearby gene
CCSER1(-160992) ; GRID2(+541188) ;
Upstream sequence
tagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttaagggttagggttagggttagggttagggttagggttag
Downstream sequence
TCCACTTATTATACAAGGGGTTTAGTACATTATATTCATGAACACTAAAATGAGTTTGGTGACTAATTCCCTTTTCTGCTACCAGACTGGAAAATTTCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate