Basic Information
VIS ID
TVIS10009851
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1527
Orient
+
Integrated sequence
TACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGC| |GCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAAC
Host Sequence
Chromosome
chr1
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
114899235/114356613 (Hg38)
End
114899235/114356613 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1474484; hsa-mir-1182/Downstream/2203411;
Nearest TSS
ENST00000473358/Upstream/94335; ENST00000468191/Downstream/41225;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/202050, chr1-CpG: 129/Downstream/153826
Nearby gene
SYT6(-202763) ; TRIM33(+36164) ;
Upstream sequence
ccgtctctactaaaaatacaaaaaattagccaggcgtggtggtgtgcacctgtagtcacagctacttgggaggctgaggcaggaaaatggtgtgaatctg
Downstream sequence
ggaggcggagattgcagtgagctgagatcgtgccactgcactccagcctgggcgacagagcgagactccatctcaaaaaaaaaaaaaaaTTCATTTTAgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate