Basic Information
VIS ID
TVIS10009859
Fusion event
HBV-LOC105378642 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2772
Orient
+
Integrated sequence
ATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGG| |TATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAG
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
35182695/34717094 (Hg38)
End
35182695/34717094 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105378642
Nearest miRNA
hsa-mir-12136/Upstream/47400; hsa-mir-101-1/Downstream/2444469;
Nearest TSS
ENST00000473358/Upstream/539424; ENST00000338513/Downstream/37953;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/539671, chr1-CpG: 22/Downstream/44333
Nearby gene
C1orf94(-497964) ; GJB5(+38026) ;
Upstream sequence
CTCTCCCTTGACCTCCAGCAACAAACAGGCTCCAGGTGCCTCCAGGCTAAAGGTGGCCTTCCCAGGAtggaattagatctggattcaagttcaggctcca
Downstream sequence
tcacctaccagctgtattcaccttgagccagtcattccatctctgtatttcagcctctacatctgtgaagtggaaataacagccactaactcagacgaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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