Basic Information
VIS ID
TVIS10009865
Fusion event
HBV-MIR548AP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2438
Orient
+
Integrated sequence
CTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCG| |GGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
84301197/83835514 (Hg38)
End
84301197/83835514 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA1L
Target gene
MIR548AP
Nearest miRNA
hsa-mir-101-1/Upstream/6775312; hsa-mir-11399/Downstream/1298280;
Nearest TSS
ENST00000473358/Upstream/45234; ENST00000646678/Downstream/25032;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2032151, chr1-CpG: 50/Downstream/25070
Upstream sequence
taataactatctcttatggttgtaaaatattgtaaagtgtttagcaccatgataaacacataagaaccattcaGCAGGTTACTATTGCAGTCACTGTATT
Downstream sequence
GTTAGGAGTAGGAAATTTCTGCAAAAGGACATGAGTCTACCATTCACATGGCTGCAGATTTTTTCTGTCTTCAGCCTTTGGCTAAGAAATACACTTTACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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