Basic Information
VIS ID
TVIS10009866
Fusion event
HBV-MIR548AP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1656
Orient
-
Integrated sequence
GTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACA| |TAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATT
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
84301206/83835523 (Hg38)
End
84301206/83835523 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA1L
Target gene
MIR548AP
Nearest miRNA
hsa-mir-101-1/Upstream/6775321; hsa-mir-11399/Downstream/1298271;
Nearest TSS
ENST00000473358/Upstream/45243; ENST00000646678/Downstream/25023;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2032160, chr1-CpG: 50/Downstream/25061
Upstream sequence
tctcttatggttgtaaaatattgtaaagtgtttagcaccatgataaacacataagaaccattcaGCAGGTTACTATTGCAGTCACTGTATTGTTAGGAGT
Downstream sequence
AGGAAATTTCTGCAAAAGGACATGAGTCTACCATTCACATGGCTGCAGATTTTTTCTGTCTTCAGCCTTTGGCTAAGAAATACACTTTACTGTTTTACAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate