Basic Information
VIS ID
TVIS10009868
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
96446651/95981095 (Hg38)
End
96446651/95981095 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1M
Nearest miRNA
hsa-mir-101-1/Upstream/1437316; hsa-mir-11399/Downstream/2064147;
Nearest TSS
ENST00000473358/Upstream/43194; ENST00000634962/Downstream/10891;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/746509, chr1-CpG: 64/Downstream/740451
Nearby gene
LINC01761(-501739) ; PTBP2(+740524) ;
Upstream sequence
agttttcttgtttcttaaagtgaaaacttatatcatcgatttgagaagtttcttcctttcttatataagattttaataataggaatttttctcttatcgt
Downstream sequence
caacctgcatctccccaatttttatgttgcaattttattttcatttagttaaaaatattttccaatttccctagtgattaaagtcttgagtaatttggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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