Basic Information
VIS ID
TVIS10009876
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1727
Orient
-
Integrated sequence
GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA| |AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
45844553/45349105 (Hg38)
End
45844553/45349105 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10G
Nearest miRNA
hsa-mir-1265/Upstream/185017; hsa-mir-107/Downstream/3636407;
Nearest TSS
ENST00000439456/Upstream/33497; ENST00000483623/Downstream/25071;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/124350, chr10-CpG: 106/Downstream/24165
Nearby gene
OR13A1(-33497) ; ALOX5(+25071) ;
Upstream sequence
agtcatcaccactccctaatctcaagtacccagggacacaaacactgctgaaggctgcagggacctctgcctaggaaaaccagagacctttgttcacctg
Downstream sequence
tttatctgctgaccttctctccactattatactatgactctgccacatccccctctctgagaaacacccaagaatgatcaataaatactaaaaaaacaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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