Basic Information
VIS ID
TVIS10009881
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2434
Orient
+
Integrated sequence
GAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAAT| |CTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAA
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
18281416/18259869 (Hg38)
End
18281416/18259869 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA11C ; FRA11I
Nearest miRNA
hsa-mir-210/Upstream/2290248; hsa-let-7a-2/Downstream/127918;
Nearest TSS
ENST00000527297/Upstream/11226; ENST00000532858/Downstream/6305;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/50510, chr11-CpG: 73/Downstream/62209
Nearby gene
SAA2-SAA4(-11195) ; SAA1(+6392) ;
Nearest cancer related gene
SAA1(TSG, +6392) ;
Upstream sequence
AGAGTTTTTTCTTAATGAGCAAAAGACAGTCGTGCCTAGGAGATGTGGTGTACATGTTAGAAAGAAGGGACTGGCTGTGACTCTATAAAAGATGAATTCA
Downstream sequence
TACAAAAACAAATTACCCTTTCCCAGGGAGAAAGTTTGGATCCAGTAATTAGAGATCTCAAAAAGTAGAAGACCTGCCCTGTGAGGCCTGTGGCCTCCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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