DLG2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009888
Fusion event
HBV-DLG2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1838
Orient
+
Integrated sequence
GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCT| |AATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACT
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
84185610/84474567 (Hg38)
End
84185610/84474567 (Hg38)
Orient
+
Location type
Intronic
Target gene
DLG2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10392/Upstream/2583731; hsa-let-7a-2/Downstream/1803766;
Nearest TSS
ENST00000527297/Upstream/36758; ENST00000534275/Downstream/246259;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1188074, chr11-CpG: 24/Downstream/1153732
Upstream sequence
GAGGCCCCAGGGCTGTTTTCTGGCACTTGCTTGAATTTCACTTTTTGCCAATGAGTGTGTTGAAGCCAACTCCTATAGACAATATATTCTCTTTatcatg
Downstream sequence
tgagataggattcccattctatacatgaggcaacaggctcagataaataaatttgtccaaattaacacagccaattggtagcagattctgaatacaaata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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