Basic Information
VIS ID
TVIS10009893
Fusion event
HBV-ADGRD1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1876
Orient
+
Integrated sequence
AGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCA| |AGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCC
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
131463215/130978670 (Hg38)
End
131463215/130978670 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ADGRD1
Nearest miRNA
hsa-let-7i/Upstream/2684492; hsa-mir-6763/Downstream/1603327;
Nearest TSS
ENST00000382841/Upstream/1108; ENST00000537600/Downstream/8139;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/44997, chr12-CpG: 21/Downstream/25481
Upstream sequence
ACGTGAATTGATACTTAAATATAAGCTGTTGCTCAGGTAGAAGTCATTGTTTTGTGCGTTGAGTTAACTAAATGAAAAGCTTGGTTACCGGCACCATGGA
Downstream sequence
TGGCCTTCGATCTACCCTTACCTAACACCACATGGaatttttttatttttatttttCTTCCTGAACAGAAAGACATTTGGCCAAGACAGGCTCATTTTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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