Basic Information
VIS ID
TVIS10009895
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1802
Orient
-
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
52555802/52162018 (Hg38)
End
52555802/52162018 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12A
Nearest miRNA
hsa-mir-1244-3/Upstream/1927806; hsa-let-7i/Downstream/736871;
Nearest TSS
ENST00000382841/Upstream/57721; ENST00000640420/Downstream/2097;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/9439, chr12-CpG: 79/Downstream/70991
Nearby gene
ATG101(-84523) ; KRT80(+6978) ;
Upstream sequence
cttttctttgtgtgtgtgtgtgtgtgtgtgtgtgtgagacagagtcttactctgtcaccaggctggagtgcagtggcataatctcagctcactgcaacct
Downstream sequence
ctgcctcccggtttcaagtgattctcctgcctcagccccctgagtagctgggactacaggtgcacaccaccacgcccagttgatttttgtatttttagta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate