Basic Information
VIS ID
TVIS10009900
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
70230182/69763465 (Hg38)
End
70230182/69763465 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA14C
Nearest miRNA
hsa-mir-208a/Upstream/2321535; hsa-mir-1185-1/Downstream/2753355;
Nearest TSS
ENST00000550708/Upstream/36565; ENST00000557435/Downstream/3628;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/36227, chr14-CpG: 99/Downstream/3388
Nearby gene
SUSD6(-48321) ; LOC100289511(+2818) ;
Upstream sequence
ctaccccaccccatcAgcaaatgttttctgtaaaggaccagacagtaaatattttaggctttcaggccatatggcctctaccgtagctactcagccccgc
Downstream sequence
ctttgtagcacaacagatataggcaataagtaaatgaacaggagtggctgtgttccaaaaatttattcatttatggatactgacctttaaatttcatata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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