Basic Information
VIS ID
TVIS10009907
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2411
Orient
-
Integrated sequence
CCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATC| |GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
38914106/38621905 (Hg38)
End
38914106/38621905 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/1649004; hsa-mir-10393/Downstream/3069680;
Nearest TSS
ENST00000557528/Upstream/56330; ENST00000557946/Downstream/6100;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/56448, chr15-CpG: 109/Downstream/958421
Nearby gene
RASGRP1(-57099) ; LINC02694(+74693) ;
Upstream sequence
AAAATTGAAATGATCTCAGAAAATTGAACATGTTATACATCATGCCCATGGCTTGCAAAATCAGAAGCAGCAACATGTAAAGGATTTAAAAAGATGGTAA
Downstream sequence
TATCATGGAAATAAGAAATACAAACTTTGTCACTTCATGCTGTCCCAACTAAAGAGTACCTGTGGGATTGAGGTGGCCACCAGATATAGCATCTGTGGAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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