Basic Information
VIS ID
TVIS10009909
Fusion event
HBV-LOC105370826 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1516
Orient
-
Integrated sequence
CGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACC| |GACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGA
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
53695545/53403348 (Hg38)
End
53695545/53403348 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105370826
Nearest miRNA
hsa-mir-10393/Upstream/1126148; hsa-mir-11181/Downstream/1969592;
Nearest TSS
ENST00000557528/Upstream/286983; ENST00000561210/Downstream/137732;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/597069, chr15-CpG: 33/Downstream/356110
Nearby gene
ONECUT1(-613336) ; WDR72(+110393) ;
Upstream sequence
CAATCTCATTCCAGATTTAAATTTCACTATATATATTTTACAAAGCCCAGGCCAGCTGTGGAATTTCCAGTTCCTTCTGATCCATTTTAACACAATTCCT
Downstream sequence
ATAAGTTTATCTTTCACGCTTTTCTTTTTCAAGGTCTGACCCAGGAAATTTACATTTCTAGGatattaaaaaaaaaaaaaaaaGACAACAACAACAACAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate