Basic Information
VIS ID
TVIS10009910
Fusion event
HBV-LOC105370826 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2429
Orient
+
Integrated sequence
TTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATC| |TCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTG
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
53695550/53403353 (Hg38)
End
53695550/53403353 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105370826
Nearest miRNA
hsa-mir-10393/Upstream/1126153; hsa-mir-11181/Downstream/1969587;
Nearest TSS
ENST00000557528/Upstream/286988; ENST00000561210/Downstream/137727;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/597074, chr15-CpG: 33/Downstream/356105
Nearby gene
ONECUT1(-613341) ; WDR72(+110388) ;
Upstream sequence
TCATTCCAGATTTAAATTTCACTATATATATTTTACAAAGCCCAGGCCAGCTGTGGAATTTCCAGTTCCTTCTGATCCATTTTAACACAATTCCTATAAG
Downstream sequence
TTTATCTTTCACGCTTTTCTTTTTCAAGGTCTGACCCAGGAAATTTACATTTCTAGGatattaaaaaaaaaaaaaaaaGACAACAACAACAACAAAAAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate