VISDB Viral Integration Site DataBase

VIS ID

TVIS10009920

Fusion event

HBV-HLF integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2612

Orient

+

Integrated sequence

GTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTA| |ATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGA

Chromosome

chr17

Cytoband

q22

Reference genome

Start

End

53391952/55314591 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-5004-3p ; hsa-mir-2053 ; hsa-mir-548s ; hsa-mir-569 ; hsa-mir-3926 ; hsa-mir-4320 ; hsa-mir-4289 ; hsa-mir-5197-5p ; hsa-mir-664a-3p ; hsa-mir-5692a ; hsa-mir-600 ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-3941 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-374c-3p ; hsa-mir-29a-5p

Nearest miRNA

hsa-mir-10226/Upstream/4545861; hsa-mir-1250/Downstream/1576679;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/48918, chr17-CpG: 98/Downstream/106291

Nearest cancer related gene

HLF(OG, No orient, 0)

Upstream sequence

CTCAGCATCTCTCACTGACATTTGGATTGTTCAAAATCATATCCCCACTGCCCACCTTCTTGGCCACATCTCTTGTGCTTGCACCTCTCCCCACTCTGTT

Downstream sequence

TTCTTCTGATTCAATGTGACAGCTACCCAAGACTATACGTGGTTCTGCAAAAATGCAAACCTCTGTCTTGTCTTGGCACCTAGAATACCCTTTTTTTGCT