VISDB Viral Integration Site DataBase

VIS ID

TVIS10009921

Fusion event

HBV-HLF integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1357

Orient

-

Integrated sequence

CTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCG| |CAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGAC

Chromosome

chr17

Cytoband

q22

Reference genome

Start

End

53391963/55314602 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-5004-3p ; hsa-mir-2053 ; hsa-mir-548s ; hsa-mir-569 ; hsa-mir-3926 ; hsa-mir-4320 ; hsa-mir-4289 ; hsa-mir-5197-5p ; hsa-mir-664a-3p ; hsa-mir-5692a ; hsa-mir-600 ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-3941 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-374c-3p ; hsa-mir-29a-5p

Nearest miRNA

hsa-mir-10226/Upstream/4545872; hsa-mir-1250/Downstream/1576668;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/48929, chr17-CpG: 98/Downstream/106280

Nearest cancer related gene

HLF(OG, No orient, 0)

Upstream sequence

TCACTGACATTTGGATTGTTCAAAATCATATCCCCACTGCCCACCTTCTTGGCCACATCTCTTGTGCTTGCACCTCTCCCCACTCTGTTTTCTTCTGATT

Downstream sequence

CAATGTGACAGCTACCCAAGACTATACGTGGTTCTGCAAAAATGCAAACCTCTGTCTTGTCTTGGCACCTAGAATACCCTTTTTTTGCTAATTACTCTTT