Basic Information
VIS ID
TVIS10009930
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1798
Orient
-
Integrated sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG| |GTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTG
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
58643703/60976470 (Hg38)
End
58643703/60976470 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA18B
Nearest miRNA
hsa-mir-1-2/Upstream/2525312; hsa-mir-5011/Downstream/6105114;
Nearest TSS
ENST00000575820/Upstream/73744; ENST00000587582/Downstream/357112;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1006575, chr18-CpG: 98/Downstream/356980
Nearby gene
MC4R(-603702) ; CDH20(+514072) ;
Upstream sequence
TCAATAATGTTTCTTCAACTGGTAAATGAATACAATCACATCAGAATGCATTTTAAAGCCATGGCTTAACTCCTAGCCAACATGTTAGCCTACAAAAGCA
Downstream sequence
ATTGAGAGACATAACATAGAAATAATTTGAAAGTAATGATATGGTGGAATTAATGTTGCCTTAATTAAAAGACcaaatgccagctcaaaatttccttcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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