Basic Information
VIS ID
TVIS10009941
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1803
Orient
-
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr2
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
21534209/21311337 (Hg38)
End
21534209/21311337 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3125/Upstream/1962832; hsa-mir-10b/Downstream/4017303;
Nearest TSS
ENST00000437798/Upstream/90152; ENST00000451511/Downstream/6323;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/267248, chr2-CpG: 256/Downstream/2073521
Nearby gene
APOB(-267264) ; LINC01822(+376097) ;
Upstream sequence
ttgttctgtcacccaggctagagtgcagtggtgtgatctcggctcactgcaagctccgcctcccaggttcacgccattctcctgcctcagcctccccacc
Downstream sequence
agctgggactacaggcgcaggctgccaaacctggctaatttttttgtatttttagtagagatggggtttcaccatgttagccaggatggtcttgatctcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate