Basic Information
VIS ID
TVIS10009952
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3036
Orient
-
Integrated sequence
CCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCC| |TTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCC
Host Sequence
Chromosome
chr2
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
226894738/226030022 (Hg38)
End
226894738/226030022 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/1019482; hsa-mir-1244-1/Downstream/628688;
Nearest TSS
ENST00000437798/Upstream/331508; ENST00000607970/Downstream/155349;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/447007, chr2-CpG: 74/Downstream/761165
Nearby gene
MIR548AR(-266557) ; LOC646736(+112772) ;
Upstream sequence
AAAAGAATACATTAAAATTTAACACTTTATGATTAAATGTAAGATTTAGGGTGTGGAGATTTCAAACTGTGAATTTGCGTAAAATTTAGTTTGCTTGTTG
Downstream sequence
CTGCTGTTTTTTTTTTCTTGTAAAGCTGTAGCTGATAAAAAGTCTTGTGAGAGAGAGAGGAGAGAGTAACTGATGCTTAGACAAAATAAAGTCATTATCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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