Basic Information
VIS ID
TVIS10009953
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1727
Orient
-
Integrated sequence
GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA| |AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
27779678/27556811 (Hg38)
End
27779678/27556811 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/2228090; hsa-mir-10b/Downstream/439556;
Nearest TSS
ENST00000437798/Upstream/19425; ENST00000408964/Downstream/19711;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/61341, chr2-CpG: 30/Downstream/26076
Nearby gene
GCKR(-33128) ; C2orf16(+19711) ;
Upstream sequence
tttattttttttttattgatcattcttgggtgtttctcgcagagggggatttggcagggtcataggacaatagtggagggaaggtcagcagataaacaag
Downstream sequence
tgaacaaaggtctctggttttcctaggcagaggaccctgcggccttggccttccgcagtgtttgtgtccctgggtacttaagattagggagtggtgatga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate