VISDB Viral Integration Site DataBase

VIS ID

TVIS10009955

Fusion event

HBV-EXOC6B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1804

Orient

-

Integrated sequence

ATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGC| |GCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT

Chromosome

chr2

Cytoband

p13.2

Reference genome

Start

End

72830246/72603117 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2E

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-25-3p ; hsa-mir-7977 ; hsa-mir-6516-3p ; hsa-mir-6849-3p ; hsa-mir-5588-3p

Nearest miRNA

hsa-mir-1285-2/Upstream/2350112; hsa-mir-10b/Downstream/2487695;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/453071, chr2-CpG: 63/Downstream/222391

Upstream sequence

GGAGTGGGTGGGAGGGAAAGAAAATAGTCAGGGTTAACTTGTGTACGGACAGATGGtttttttttttttttggttgtttttttttttAAGAGCACTTTCT

Downstream sequence

TTACCACCAGGGAATATCAATGGCCTTTTAAGCAGTTTCACATTTAAATGTGTGTTCTGACAGTCATGTCAGAGCCTGGGTAAAAGCCTTTTCATGGAAA